Clinical Research Directory

Inclusion Criteria: Subjects will be eligible for this study if they: 1. are experiencing anxiety and/or depressive symptoms, as evidenced by a BAI-C score of at least 8 (no symptoms = 0-7; mild = 8-15; moderate = 16-25; severe = 26-63) and/or a C-BDI-II score of at least 14 (no symptoms = 0-13, mild = 14-19; moderate = 20-28; severe = 29-63), with symptoms persistent for more than 3 months; and 2. are able to provide informed consent for participation, take medications and complete questionnaires as scheduled. Exclusion Criteria: Subjects will be excluded if they: 1. have unstable systemic medical conditions that may limit their participation in the study (e.g., severe liver, cardiovascular or kidney impairment; gastrointestinal or endocrine dysfunction; malignancy; autoimmune disease or acute infectious disease); 2. have bipolar disorder, psychotic disorder (e.g., schizophrenia), organic mental disorder (e.g., Alzheimer's disease), or significant cognitive impairment; 3. present suicidal ideation (a score of ≥3 for all questionnaires of the Columbia-Suicide Severity Rating Scale (C-SSRS); 4. have a history of brain injury or surgery; 5. have alcohol abuse or substance abuse; 6. are pregnant or in lactation, or are intend to conceive; 7. have use of herbal remedies in the previous 6 months; 8. have a history of hypersensitivity to investigational drug treatment or the active or inactive constituents of the tested products; 9. have treatment with brain stimulation in the previous 6 months; or 10. are involved in other interventional clinical studies in the last 3 months or any relevant condition potentially interfering with study evaluation.