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Photoacoustic Tomography in Assessment of Lower Extremity Artery Disease
Sponsor: Sun Yat-sen University
Summary
Lower extremity artery disease (LEAD) is characterized by low awareness rate and high missed diagnosis rate, leading to low treatment rate and high disabling mortality rate. However, none of the current examination methods can comprehensively and thoroughly evaluate the vascular structure and blood oxygen status of the lower extremity at the same time. Photoacoustic imaging can display millimeter-scale microvessels without the need for contrast agents. The investigators developed photoacoustic tomography (PACT) technology, which wass able to provide three-dimensional and high-resolution photoacoustic images of the target area.The investigators plan to recruit LEAD patients in different disease conditions and healthy volunteers to receive the PACT examination on the feet using this imaging system, and to evaluate the potential clinical role of the imaging system in LEAD, and its added value to current imaging methods.
Official title: Multistructural Quantitative Photoacoustic Imaging of Human Feet With Lower Extremity Artery Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2024-11-01
Completion Date
2025-12-31
Last Updated
2025-08-22
Healthy Volunteers
Yes
Conditions
Interventions
Photoacoustic imaging
It could provide three-dimensional ultrasound images of vessels in the target area. It could also provides super-resolution and large-depth photoacoustic images. By effectively extracting photoacoustic spectral features and using spectral feature unmixing algorithm, blood oxygen saturation can be calculated.
Locations (1)
the Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China