Clinical Research Directory

Inclusion Criteria: 1. Community-dwelling adults aged 50-75 years; 2. Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period; 3. Subjects with written informed consents. Exclusion Criteria: 1. Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system); 2. Life expectancy of ≤4 years due to serious diseases such as end-stage cancer; 3. Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others); 4. Residents who are participating in other studies.