Clinical Research Directory

Inclusion Criteria: * Participant is able to provide informed consent * English speaker * 18 years of age or older at time of consent * Meets DSM-5 criteria for Major Depressive Disorder * The subject meets eligibility criteria for at least one study phenotype as determined by assessments, imaging and/or clinical judgment. * PHQ-8 score at baseline of \>= 10 * Scheduled for or completed intake in UCSF outpatient psychiatry Exclusion Criteria: * Unstable or untreated medical or psychiatric condition based on clinical assessment by investigator(s) * Significant risk of suicidal or violent behavior as determined by clinical judgement * In the Investigators' opinion, the subject is not capable of adhering to the protocol requirements, or the subject has a history of poor or suspected poor compliance in clinical research studies, or the subject has a history of poor or suspected poor compliance to antidepressant medication or that study participation is not in their best interest (e.g., different treatment is indicated given their clinical presentation) * Pregnant or breastfeeding or planning to become pregnant during the study