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Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas
Sponsor: Assiut University
Summary
1. Identify randomized controlled trials of tamoxifen (Estrogen Receptor modulator) in in addition to traditional treatment of bipolar disorder and synthesize the results using meta-analysis. 2. Systematically estimate the effects of Phospholipase C epsilon 1 gene (PLCE1) rs2274223and gene polymorphism on the susceptibility to treatment. 3. Study the pathway involved in the action of tamoxifen by incorporating TMX into nanoparticles and evaluating tyrosine kinase in responders WBCS culture and evaluate nanoparticle as a hope for future treatment of CNS disorders.
Official title: Impact of Estrogen Receptor Modulators on Mania Patients and Its Relationship With Genetic Polymorphism of Phospholipase C Epsilon1
Key Details
Gender
All
Age Range
15 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2024-09-05
Completion Date
2025-12
Last Updated
2024-08-30
Healthy Volunteers
Not specified
Conditions
Interventions
blood sample
Blood sample taking from patient for tissue culture