Clinical Research Directory

Inclusion Criteria: * Invasive mechanical ventilation (MV) started in the ICU within the past 24 h, or started before ICU admission with ICU admission within the past 24 h, and expected to be required for at least 48 hours after randomization * Treatment with a vasoactive agent for shock (adrenaline, dobutamine, or noradrenaline) * Nutritional support expected to be started within 24 h after intubation (or within 24 h after ICU admission if intubation occurred before ICU admission) * Age 18 or older * Patient and/or next-of-kin informed about the trial and having consented to participation in the trial. If the patient is unable to receive information and no next-of-kin can be contacted during screening for the trial, trial inclusion will be completed as an emergency procedure by the ICU physician, in compliance with French law. * Covered by the French public health-insurance system Exclusion Criteria: * MV started more than 24 hours earlier * Specific nutritional needs, such as pre-existing long-term home enteral or parenteral nutrition for chronic bowel disease * Dying patient, do-not-resuscitate order, or other treatment- limitation decision at ICU admission * Social circumstances hindering follow-up and telephone/video consultations (no fixed address, non-European residence) * Inability to provide a stable personal mobile phone number (temporary number or not in the owner's name) * Communication difficulties via telephone or video consultation (pre-existing severe hearing or visual impairment) * Pre-existing chronic illness with life expectancy \<6 months * Pre-existing cognitive impairment * Pre-existing spinal injury * Inability to walk before the critical illness * Acute or chronic neuromuscular disease * Brain injury, e.g., due to cardiac arrest, stroke, or severe trauma * Pregnancy, recent delivery, or lactation * Adult under guardianship * Correctional facility inmate * Institutionalized patient * Prior inclusion in a randomized trial designed to compare rehabilitation programs delivered to patients during critical illness