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Individualized First Maintenance Doses of Voriconazole Through a Multiparametric Algorithm
Sponsor: University Hospital, Grenoble
Summary
The goal of this interventional single-arm study is to evaluate the interest of a multiparametric algorithm for individualization of first voriconazole maintenance doses for improvement of initial voriconazole exposure in adult patients with haematological malignancies. The main objective it aims is to determine the percentage of patients with initial voriconazole trough concentrations in the therapeutic range after individualization of first maintenance doses. Participants will benefited from individualization of first voriconazole maintenance doses through a previously developed and validated multiparametric algorithm (publication in progress) taking into account CYP2C19 genotype, C reactive protein level and age.
Official title: Individualization of First Maintenance Doses of Voriconazole Using a Multiparametric Algorithm in Hematology Patients: a Prospective Single-arm Interventional Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2024-10
Completion Date
2027-10
Last Updated
2024-09-03
Healthy Volunteers
No
Interventions
Individualization of first voriconazole maintenance doses
Individualization of first voriconazole maintenance doses
Locations (1)
Gautier-Veyret
Grenoble, France