Clinical Research Directory

Inclusion Criteria: * In general, study participants must: 1. Be informed of the nature of the study and provide written informed consent before any study-specific procedures are performed. 2. Be 18- to 80-years-of-age, inclusive, at time of consent. 3. Have suitable venous access for at least a single venipuncture. 4. Eligible patients on anticoagulants must have taken their prescribed anticoagulant regularly at least for one month prior to study participation for inclusion Exclusion Criteria: * Eligible patients on anticoagulants must not: 1. Other than the condition for which a DOAC was prescribed , have a personal or family history of clotting disorder or hematologic abnormality, such as excessive bleeding, joint hematoma, thrombovascular disease, thrombocytopenia, or any chronic condition requiring treatment with transfusions. 2. Have a BMI\> 40 or weight \> 120kg. 3. Suffer from renal or hepatic insufficiency. 4. Suffer from any pathology that would contra-indicate in general DOAC medication. 5. Have a history of unexplained syncope. 6. Have a history within 6 months prior to Screening of peptic ulcer or gastrointestinal bleeding (including hematemesis, melena, or rectal bleeding). 7. Consume more than 5 cigarettes per day. 8. If female, have a history of excessive or dysfunctional uterine bleeding (unless the subject had a subsequent hysterectomy). 9. If female is pregnant, breastfeeding, or planning to become pregnant during study