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Drinking, Acetate, and Stress
Sponsor: Yale University
Summary
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.
Official title: Role of Acetate in Heavy Drinking
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-11-06
Completion Date
2030-01
Last Updated
2025-07-28
Healthy Volunteers
Yes
Conditions
Interventions
Deuterium Metabolic Imaging with deuterated acetate tracer
Deuterium Metabolic Imaging (DMI) is a method by which Magnetic Resonance Spectroscopy (MRS) is used to map the appearance of deuterium from a tracer source (e.g., deuterated acetate) in products of metabolism. In this case we will map the combination of glutamate and glutamine, called Glx, to serve as a tag to measure the brain's rate of acetate consumption. That is, the more deuterium appears in Glx, the more acetate that part of the brain consumes.
Locations (2)
The Anlyan Center, 300 Cedar St.
New Haven, Connecticut, United States
Yale University
New Haven, Connecticut, United States