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Investigating How Childhood Tumours and Congenital Disease Develop
Sponsor: The Wellcome Sanger Institute
Summary
Every cell and every organ in the human body derives from a fertilised egg. As the fertilised egg divides, a human being develops and grows. The process of how the fertilised egg divides and forms a human being is very sophisticated and is directed by the genetic information, the DNA, that is present in every cell. When errors, mutations, in the DNA code arise, the orderly process of human development can be disrupted. This can lead to the development of tumours during childhood and congenital diseases (that is, abnormalities that children are born with). The aim of this study is to define exactly which DNA errors underpin childhood tumours and congenital diseases.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2017-02-02
Completion Date
2026-02-28
Last Updated
2024-09-05
Healthy Volunteers
Yes
Conditions
Interventions
sample collection
Surplus material from surgery. New or stored blood or saliva. Semen (from adult males).
Seeking consent and assent
Consent or assent from all participants to be included in the study. Consent from parent / guardian for inclusion of children in study (as primary participant or relative/sibling, as applicable).
Locations (1)
Wellcome Sanger Institute
Cambridge, United Kingdom