Clinical Research Directory

Inclusion criteria: * Minimum of child affected with cancer pre-disposition syndromes and their father * Additional family members of consented father and child duos (Mother, same parent siblings, Maternal/Paternal Aunts, uncles and grandparents of affected child) * Reproductive tissue samples from both men and women affected by cancer collected with consent for use in research. * Reproductive tissue samples from both men and women unaffected by cancer collected with consent for use in research. Exclusion: * Fathers who do not wish to donate a semen sample or are unable to will be excluded from the study, as will their families * Fathers who have had a vasectomy will be excluded from the study as will their families * Adults who do not have the capacity to consent for themselves will be excluded from the study. * Families in which both parents do not have capacity to consent will also be excluded as they will be unable to give parental consent for their children's participation. * In order to be eligible siblings must share the same two parents as the affected child, all other siblings will be excluded from the study. * Male relatives in the extended family (Maternal/Paternal Aunts, uncles and grandparents of affected child) unwilling or unable to donate both a blood or saliva sample and a semen sample will be excluded from the study. * Participants who do not have a good understanding of the English language will be excluded from the study.