Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Summary
The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease
Key Details
Gender
All
Age Range
55 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
406
Start Date
2024-09-26
Completion Date
2026-10-19
Last Updated
2026-04-01
Healthy Volunteers
No
Conditions
Interventions
KarXT
Specified dose on specified days
Placebo
Specified dose on specified days
Locations (281)
Chandler Clinical Trials, LLC
Chandler, Arizona, United States
Gilbert Neurology Partners - PLLC - Avacare
Gilbert, Arizona, United States
Banner Alzheimer's Institute
Phoenix, Arizona, United States
Scottsdale Clinical Trials
Scottsdale, Arizona, United States
Advanced Research Center, Inc.
Anaheim, California, United States
Inland Psychiatric Medical Group (IPMG)-Chino
Chino, California, United States
Long Beach Research Institute, LLC
Long Beach, California, United States
USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC)
Los Angeles, California, United States
Local Institution - 1219
Los Angeles, California, United States
Local Institution - 1001
Orange, California, United States
NRC Research Institute - Orange - PPDS
Orange, California, United States
SC3 Research - Pasadena - 960 E. Green St
Pasadena, California, United States
Prospective Research Innovations 8577 Haven Ave
Rancho Cucamonga, California, United States
University of Connecticut Health Center
Farmington, Connecticut, United States
Genesis Trust Research Group
Atlantis, Florida, United States
Envision Trials LLC
Bonita Springs, Florida, United States
JY Research Institute Inc
Cutler Bay, Florida, United States
Arrow Clinical Trials
Daytona Beach, Florida, United States
Quantum Laboratories, Inc - West Palm Beach Office
Deerfield Beach, Florida, United States
Integrity Clinical Research LLC - 21st Street
Doral, Florida, United States
New Life Medical Research Center -3750 W 16th Ave
Hialeah, Florida, United States
Research in Miami, Inc
Hialeah, Florida, United States
Nexus Clinical Research Center- NRC
Homestead, Florida, United States
K2 Medical Research - Lady Lake
Lady Lake, Florida, United States
Homestead Associates in Research Inc
Miami, Florida, United States
Premier Clinical Research Institute
Miami, Florida, United States
Wellness Research Center Inc - Miami
Miami, Florida, United States
A & D Doctor Center
Miami, Florida, United States
Floridian Neuroscience Institute-1901 SW 1 St
Miami, Florida, United States
Miami Jewish Health Systems
Miami, Florida, United States
MedOne Clinical Research LLC
Miami, Florida, United States
My Community Research Center, Inc - 7480 Bird Rd
Miami, Florida, United States
Future Care Solution LLC
Miami, Florida, United States
Reliant Medical Research
Miami, Florida, United States
Novel Clinical Research Center, LLC.
Miami, Florida, United States
Dade Research Center - Miami FL - 7600 SW 87th Ave
Miami, Florida, United States
Local Institution - 1158
Miami, Florida, United States
Serenity Research Center
Miami, Florida, United States
IMIC LLC- 9380 SW 150th Str
Miami, Florida, United States
New Gen Health
Miami, Florida, United States
Floridian Research Institute- Ives Dairy Road
Miami, Florida, United States
High Quality Research
Miami, Florida, United States
New Med Research
Miami Gardens, Florida, United States
Panax Clinical Research
Miami Lakes, Florida, United States
Angels Clinical Research Institute - Miami Lakes - Palm Springs - PPDS
Miami Lakes, Florida, United States
Aqualane Clinical Research
Naples, Florida, United States
Sensible HealthCare, LLC
Ocoee, Florida, United States
Local Institution - 1257
Orlando, Florida, United States
Nova Psychiatry
Orlando, Florida, United States
Combined Research Orlando Phase I-IV LLC
Orlando, Florida, United States
Neurology Associates of Ormond Beach
Ormond Beach, Florida, United States
Progressive Medical Research (Duplicate)
Port Orange, Florida, United States
Cordova Research Institute- Sweetwater
Sweetwater, Florida, United States
Angels Clinical Research Institute Tampa - Palm Springs - PPDS
Tampa, Florida, United States
Guardian Angel Research
Tampa, Florida, United States
Interventional Psychiatry of Tampa Bay
Tampa, Florida, United States
Local Institution - 1233
Wellington, Florida, United States
Premiere Research Institute at Palm Beach Neurology, PA
West Palm Beach, Florida, United States
Agile Clinical Research Trials, LLC
Atlanta, Georgia, United States
McLean Hospital
Belmont, Massachusetts, United States
Tufts Medical Center - 800 Washington St - PPDS
Boston, Massachusetts, United States
Boston Neuro Research Center
North Dartmouth, Massachusetts, United States
Local Institution - 1250
South Dartmouth, Massachusetts, United States
Elixia Health - Springfield - Elixia - PPDS
Springfield, Massachusetts, United States
Neurobehavioral Medicine Group (NBMG)
Bloomfield Township, Michigan, United States
Precise Research Centers
Flowood, Mississippi, United States
Local Institution - 1255
St Louis, Missouri, United States
Advanced Memory Research Institute - CenExel - PPDS
Toms River, New Jersey, United States
Bio Behavioral Health
Toms River, New Jersey, United States
Local Institution - 1251
New Windsor, New York, United States
Local Institution - 1231
Syracuse, New York, United States
Local Institution - 1240
Syracuse, New York, United States
Five Towns Neurology, PC
Woodmere, New York, United States
Triad Clinical Trials - 515 College Rd
Greensboro, North Carolina, United States
AMC Research, LLC - Flourish - PPDS
Matthews, North Carolina, United States
Local Institution - 5005
Morehead City, North Carolina, United States
West Clinical Research
Morehead City, North Carolina, United States
Local Institution - 1252
Shelby, North Carolina, United States
Ohio State University
Columbus, Ohio, United States
Local Institution - 1258
Dayton, Ohio, United States
Insight Clinical Trials LLC - Independence
Independence, Ohio, United States
The Rivus Wellness & Research Institute
Oklahoma City, Oklahoma, United States
Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital
Providence, Rhode Island, United States
Vanderbilt Psychiatric Hospital
Nashville, Tennessee, United States
Epic Medical Research LLC - DeSoto - HyperCore - PPDS
DeSoto, Texas, United States
Advanced Neuro Research Center - El Paso
El Paso, Texas, United States
AIM Trials
Plano, Texas, United States
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases
San Antonio, Texas, United States
Local Institution - 1134
Stafford, Texas, United States
Conquest Research, LLC - Virginia - Vienna
Vienna, Virginia, United States
Local Institution - 1253
Bellevue, Washington, United States
Local Institution - 1254
Kirkland, Washington, United States
CINME S.A. - Centro de Investigaciones Metabólicas - Viamonte 2213/2215
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 5005
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Fundación para el Estudio y Tratamiento de Enfermedades mentales- FETEM
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 5008
Rosario, Santa Fe Province, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
Local Institution - 5009
Buenos Aires, Argentina
Local Institution - 5006
Buenos Aires, Argentina
Instituto Privado Kremer
Córdoba, Argentina
Local Institution - 5007
San Rafael, Argentina
UZ Brussel - PPDS
Jette, Brussels Capital, Belgium
AZ Delta- Campus Rumbeke
Roeselare, West-Vlaanderen, Belgium
ANIMA Research Center - PPDS
Alken, Belgium
Local Institution - 2807
Bruges, Belgium
AZ Groeninge
Kortrijk, Belgium
L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME
Brasília, Federal District, Brazil
CPQuali Pesquisa Clínica Sao Paulo
São Paulo, São Paulo, Brazil
BR Trials - Pesquisa Clínica
São Paulo, São Paulo, Brazil
Local Institution - 6207
São Paulo, São Paulo, Brazil
Clinilive
São Paulo, São Paulo, Brazil
Ruschel Medicina
Rio de Janeiro, Brazil
Instituto de Psiquiatria HC FMUSP
São Paulo, Brazil
Medical Center Intermedica OOD
Sofia, Sofia-Grad, Bulgaria
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD-66 Peshtersko Shosse blvd
Plovdiv, Bulgaria
University Multiprofile Hospital For Active Treatment Kanev AD
Rousse, Bulgaria
Medical Center Medika 2005 - Branch Sofia
Sofia, Bulgaria
Local Institution - 4510
Sofia, Bulgaria
Local Institution - 7004
Beijing, Beijing Municipality, China
Local Institution - 7005
Beijing, Beijing Municipality, China
Local Institution - 7025
Beijing, Beijing Municipality, China
Local Institution - 7015
Chongqing, Chongqing Municipality, China
Local Institution - 7008
Guangzhou, Guangdong, China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
Local Institution - 7003
Shenzhen, Guangdong, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Local Institution - 7024
Nanjing, Jiangsu, China
Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, China
Shanghai Mental Health Center - PPDS
Shanghai, Shanghai Municipality, China
Tongji Hospital of Tongji University
Shanghai, Shanghai Municipality, China
Local Institution - 7026
Shanghai, Shanghai Municipality, China
Local Institution - 7002
Chengdu, Sichuan, China
Local Institution - 7019
Tianjin, Tianjin Municipality, China
Local Institution - 7020
Hangzhou, Zhejiang, China
Local Institution - 7021
Hangzhou, Zhejiang, China
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Local Institution - 7027
Changsha, China
Local Institution - 7022
Kunming, China
Local Institution - 4106
Zagreb, City of Zagreb, Croatia
Polyclinic Neuron
Zagreb, City of Zagreb, Croatia
University Hospital Center Zagreb
Zagreb, City of Zagreb, Croatia
Klinika za psihijatriju Vrapce
Zagreb, City of Zagreb, Croatia
Psychiatric Clinic Sveti Ivan
Zagreb, City of Zagreb, Croatia
Institut Claude Pompidou
Nice, Alpes-Maritimes, France
CHRU de Tours - Hôpital Bretonneau
Tours, Indre-et-Loire, France
Local Institution - 2512
Toulouse, France
CHU de Toulouse- Gerontopole
Toulouse, France
Local Institution - 2407
Böblingen, Baden-Wurttemberg, Germany
Universitatsklinikum des Saarlandes
Homburg, Saarland, Germany
Local Institution - 2406
Berlin, Germany
NeuroCentrum Odenwald
Erbach im Odenwald, Germany
Universitätsklinikum Frankfurt
Frankfurt am Main, Germany
Henry Dunant Hospital Center
Athens, Attica, Greece
University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA
Chaidari, Athens, Attica, Greece
General Oncology Hospital of Kifissia ''Agioi Anargyroi''
Kalyftaki-N. Kifissia, Attica, Greece
PAGNI-University General Hospital of Heraklion
Heraklion, Irakleio, Greece
424 General Military Training Hospital-Outpatient Psychiatric Department
Thessaloniki, Greece
Psychotech Kft.
Pécs, Baranya, Hungary
Local Institution - 4610
Szeged, Csongrád megye, Hungary
Clinexpert Gyöngyös Kft.
Gyöngyös, Heves County, Hungary
Semmelweis Egyetem Pszichiátriai és Pszichoterápiás Klinika
Budapest, Hungary
Eszak-budai Szent Janos Centrumkorhaz
Budapest, Hungary
Central Institute of Behavioural Sciences
Nagpur, Maharashtra, India
Local Institution - 7405
Chandigarh, Punjab, India
Local Institution - 7406
Ajmer, Rajasthan, India
Asha Hospital - Hyderabad
Hyderabad, India
Institute of Neurosciences Kolkata
Kolkata, India
Deva Institute of Healthcare & Research (DIHR) Pvt Ltd (Deva Institute of Healthcare)
Varanasi, India
Hadassah Medical Center- Ein Kerem - PPDS
Jerusalem, Jerusalem, Israel
The Barzilai University Medical Center
Ashkelon, Tel Aviv, Israel
Rabin Medical Center - PPDS
Petah Tikva, Israel
The Chaim Sheba Medical Center - PPDS
Ramat Gan, Israel
Local Institution - 2325
Salerno, Campania, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I - Viale del Policlinico 155
Rome, Lazio, Italy
Local Institution - 2320
Rome, Lazio, Italy
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
Brescia, Lombardy, Italy
Auxologico IRCCS - Auxologico San Luca
Milan, Lombardy, Italy
ASL Biella - Ospedale degli Infermi
Ponderano (Biella), Piedmont, Italy
Local Institution - 2321
Rome, Roma, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea
Roma, Italy
Iizuka Memorial Hospital
Iizuka, Fukuoka, Japan
Southern TOHOKU Medical Clinic
Kōriyama, Fukushima, Japan
Local Institution - 7522
Sapporo, Hokkaido, Japan
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-Shi, Hyōgo, Japan
Memory Clinic Toride
Toride-shi, Ibaraki, Japan
Kagawa Prefectural Central Hospital
Takamatsu, Kagawa-ken, Japan
Hatano Kousei Hospital
Hadano, Kanagawa, Japan
Koukan Clinic
Kawasaki-Shi, Kanagawa, Japan
Tsurumi Nishii Hospital
Yokohama, Kanagawa, Japan
Yokohama City Minato Red Cross Hospital
Yokohama, Kanagawa, Japan
Yokohama City University Hospital
Yokohama, Kanagawa, Japan
National Hospital Organization Utano National Hospital
Kyoto, Kyoto, Japan
National Hospital Organization Miechuo Medical Center
Tsu, Mie-ken, Japan
Asakayama General Hospital
Sakai, Osaka, Japan
Shin-Abuyama Hospital
Takatsuki, Osaka, Japan
Local Institution - 7510
Kanzaki-Gun Yoshinogari-Cho, Saga-ken, Japan
Local Institution - 7504
Wako-Shi, Saitama, Japan
NHO Tokushima Medical Center West
Yoshinogawa, Tokushima, Japan
Tokyo Angel Hospital
Hachiōji, Tokyo, Japan
Sangenjaya Nakamura Mental Clinic
Setagaya-Ku, Tokyo, Japan
Kurumi Clinic
Setagaya-Ku, Tokyo, Japan
Tokyo Metropolitan Matsuzawa Hospital
Setagaya-Ku, Tokyo, Japan
Tokyo Metropolitan Geriatric Hospital
tabashi City, Tokyo, Japan
Local Institution - 7515
Fukuoka, Japan
Funairi nou clinic
Hiroshima, Japan
Yuge Neuropsychiatric Hospital
Kumamoto, Japan
Tsutsujimental Hospital
Tatebayashi, Japan
Centrum Medyczne HCP Szpital im. Jana Pawla II
Poznan, Greater Poland Voivodeship, Poland
Uniwersyteckie Centrum Kliniczne w Gdansku - Smoluchowskiego 17
Gdansk, Pomeranian Voivodeship, Poland
Osrodek Badan Klinicznych BD Research Sp. z o.o. - Andersa 3
Iława, Warmian-Masurian Voivodeship, Poland
Osrodek Badan Klinicznych BD Research Sp. z o.o. - Andersa 3
Iława, Warmian-Masurian Voivodeship, Poland
Local Institution - 4213
Kielce, Poland
Pro Salus Sp. z o.o.sp. k
Lodz, Poland
NZOZ NEUROMED M. I M. Nastaj Spolka Partnerska -Lublin
Lublin, Poland
Local Institution - 4216
Sochaczew, Poland
Local Institution - 4211
Wroclaw, Poland
ULS do Alto Ave, EPE - Hospital da Senhora da Oliveira Guimarães
Guimarães, Braga District, Portugal
ULS de Lisboa Ocidental, EPE - Hospital Egas Moniz
Lisbon, Lisbon District, Portugal
Campus Neurológico Sénior
Torres Vedras, Lisbon District, Portugal
ULS de Matosinhos, EPE - Hospital Pedro Hispano
Matosinhos Municipality, Porto District, Portugal
ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS
Lisbon, Portugal
Local Institution - 2706
Lisbon, Portugal
Santa Cruz Behavioral PSC
Bayamón, Puerto Rico
CDT Grupo Medico San Pablo Inc.
Bayamón, Puerto Rico
Instituto De Neurologia Dra. Ivonne Fraga,Psc
San Juan, Puerto Rico
Barbara Diaz Hernandez MD Research Inc
San Juan, Puerto Rico
Local Institution - 1305
San Juan, Puerto Rico
CMI Dr. Buhas Ramocea Elena Daniela - Cabinet Medical de Psihiarie
Oradea, Bihor County, Romania
Prof Dr Alexandru Obregia Clinical Psychiatric Hospital- Centrul de Sanatate Mintala
Bucharest, Romania
Cai Ferate Clinical Hospital Constanta
Constanța, Romania
Institutul Privat de Cercetări Melchisedec pentru Boli Autoimune, Ereditare și Rare -I.P.C.M
Craiova, Romania
Local Institution - 4905
Iași, Romania
S.C. Carpe Diem SRL
Sibiu, Romania
University Clinical Center of Serbia - Dr Subotica 6 - PPDS
Belgrade, Belgrade, Serbia
Clinical Hospital Center Dragisa Misovic Dedinje
Belgrade, Serbia
Military Medical Academy
Belgrade, Serbia
Military Medical Academy
Belgrade, Serbia
Special Hospital for Psychiatric Diseases "Gornja Toponica"
Gornja Toponica, Serbia
Special Hospital for Psychiatric Diseases Kovin
Kovin, Serbia
University Clinical Center Kragujevac
Kragujevac, Serbia
Clinical Centre of Vojvodina
Novi Sad, Serbia
Univerzitna nemocnica L Pasteura Kosice-Rastislavova 43
Košice, Košice Region, Slovakia
MUDr. Beata Dupejova - Neurologicka Ambulancia s.r.o
Banská Bystrica, Slovakia
KONZILIUM s.r.o
Dubnica nad Váhom, Slovakia
EPAMED s.r.o
Košice, Slovakia
Psychiatrická nemocnica Philippa Pinela Pezinok
Pezinok, Slovakia
Crystal Comfort, s.r.o.
Vranov nad Topľou, Slovakia
Korea University Ansan Hospital
Ansan-si, Gyeonggido, South Korea
Yongin Severance Hospital, Yonsei University Health System
Yongin-si, Gyeonggido, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, Seoul Teugbyeolsi, South Korea
Ewha Womans University Seoul Hospital
Seoul, Seoul Teugbyeolsi, South Korea
Ewha Womans University Mokdong Hospital
Seoul, Seoul Teugbyeolsi, South Korea
The Catholic University of Korea, Yeouido St. Mary's Hospital
Yeongdeungpo-gu, Seoul Teugbyeolsi, South Korea
Hallym University Chuncheon Sacred Heart Hospital
Gangwon-do, South Korea
Seoul National University Hospital
Seoul, South Korea
Local Institution - 7219
Seoul, South Korea
Local Institution - 7203
Seoul, South Korea
Hanyang University Seoul Hospital
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda, Madrid, Spain
Hospital Quironsalud Malaga
Málaga, Málaga, Spain
Hospital Universitari Santa Maria
Lleida, Spain
Hospital Clinico San Carlos
Madrid, Spain
Hospital Universitario De Salamanca
Salamanca, Spain
Hospital Victoria Eugenia
Seville, Spain
Hospital Universitario Rio Hortega
Valladolid, Spain
Local Institution - 2206
Zaragoza, Spain
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Atakum, Samsun, Turkey (Türkiye)
Hacettepe University Medical Faculty
Ankara, Turkey (Türkiye)
Eskisehir Osmangazi Universitesi Tip Fakultesi Hastanesi
Eskişehir, Turkey (Türkiye)
Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi
Istanbul, Turkey (Türkiye)
Dokuz Eylul Universitesi Arastirma ve Uygulama Hastanesi
Izmir, Turkey (Türkiye)
IEU Medical Point Izmir Hastanesi
Izmir, Turkey (Türkiye)
Local Institution - 8001
Vinnytsia, Vinnytsia Oblast, Ukraine
Local Institution - 8003
Khmelnytskyi, Ukraine
Local Institution - 8006
Lviv, Ukraine
Local Institution - 8007
Lviv, Ukraine
Local Institution - 8004
Smila, Ukraine
Local Institution - 8008
Ternopil, Ukraine
Local Institution - 8005
Uzhhorod, Ukraine
Local Institution - 8002
Vinnytsia, Ukraine