Clinical Research Directory
Browse clinical research sites, groups, and studies.
Interferon Pathway Activation in Monogenic and Nonmonogenic Forms of Pediatric SLE
Sponsor: Meyer Children's Hospital IRCCS
Summary
Pediatric SLE includes monogenic forms, some of which involve the interferon type I (IFN-I) pathway. The IFN-I pathway is renally active in adult SLE and correlates with the extent of renal damage. In pediatric SLE, and particularly in lupus nephritis, activation of the IFN-I pathway has never been studied, nor is it known whether monogenic forms underlie more pronounced interferon activation.
Official title: Interferon Pathway Activation in Monogenic and Non-monogenic Forms of Pediatric SLE With Renal Involvement. Multicenter Observational Study of Biological Samples.
Key Details
Gender
All
Age Range
1 Month - 17 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-06-07
Completion Date
2025-12-31
Last Updated
2024-09-19
Healthy Volunteers
No
Interventions
Assessment activation of interferon pathway
* Peripheral blood collection (as part of routine blood draws) on which interferon signature will be performed at the time of enrollment and in case of remission and/or any renal flare. * Renal biopsies (routinely performed for diagnostic purposes and during clinical follow-up) on which Myxovirus resistance protein 1 (MXA) expression and histopathologic characterization will be assessed. * Collection of clinical and laboratory data from routine visits performed at baseline and 3, 6, 12, and 24 months (or last available visit) after the renal biopsy was performed.
Locations (3)
Meyer Children's Hospital IRCCS
Florence, Italy
IRCCS Gianna Gaslini
Genova, Italy
IRCCS Humanitas Research Hospital
Rozzano, Italy