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NOT YET RECRUITING
NCT06587503
PHASE4

Safety and Immunogenicity of rVSVΔG-ZEBOV-GP Vaccination When Dosed Concurrently With mRNA COVID-19 Vaccine Booster Doses

Sponsor: University of Birmingham

View on ClinicalTrials.gov

Summary

Concurrent vaccination scheduling for key target populations in Rwanda, such as healthcare workers, may confer significant advantages in the provision of vaccine coverage to several infectious diseases. This is a phase IV vaccine trial that looks to establish if two licenced vaccines, the rVSVΔG-ZEBOV-GP vaccine for protection against Ebola virus and messenger ribonucleic acid (mRNA) COVID vaccine for protection against SARS-CoV-2 virus, given concurrently to self selected healthy adult volunteers confers an acceptable safety profile and immunogenicity response.

Official title: EbolaCov: A Phase IV, Single-centre, Single-blinded, Randomized Controlled Trial to Assess Safety and Immunogenicity of rVSVΔG-ZEBOV-GP Vaccination When Dosed Concurrent With mRNA COVID-19 Vaccine Booster Doses in Healthy African Adults

Key Details

Gender

All

Age Range

18 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

72

Start Date

2024-10

Completion Date

2025-05

Last Updated

2024-09-19

Healthy Volunteers

Yes

Interventions

BIOLOGICAL

BioNTech - Pfizer COVID-19 vaccine

Vaccine for protection from COVID-19

BIOLOGICAL

1mL saline solution

Placebo

BIOLOGICAL

rVSV∆G-ZEBOV-GP

Vaccine for protection from Zaire Ebola virus