Clinical Research Directory
Browse clinical research sites, groups, and studies.
Corticosteroid Effect on Achalasia Variant EGJOO
Sponsor: Baylor Research Institute
Summary
EGJOO is a disorder in which the muscles of the esophagus (swallowing tube) do not function in a coordinated fashion so that swallowed material does not pass easily into the stomach. EGJOO often causes symptoms of swallowing difficulties and chest pain. The cause of EGJOO and its optimal treatment are not clear. The investigators research team suspects that EGJOO might be caused by an allergy that involves the esophagus, and that treatment with medications called corticosteroids might improve function of the esophageal muscles. The purpose of this study is to learn how corticosteroid therapy affects the muscles of the esophagus in patients suffering with EGJOO.
Official title: Corticosteroid Effect on Achalasia Variant Esophagogastric Junction Outflow Obstruction
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2022-07-26
Completion Date
2026-11
Last Updated
2026-01-28
Healthy Volunteers
No
Interventions
Steroid treatment
All enrolled subjects will be prescribed a 14-day course of corticosteroid therapy in the form of Prednisone 20 mg to be taken once daily by mouth.
Esophageal Manometry
On the final day of Prednisone use, all subjects will undergo esophageal manometry testing to assess for treatment response.
Survey
All enrolled subjects will be asked to complete follow-up Eckardt and BEDQ surveys.
Locations (1)
Baylor University Medical Center
Dallas, Texas, United States