Clinical Research Directory

Inclusion Criteria: 1. Age 18 and 75 years, gender not specified; 2. Pathologically confirmed primary liver cancer or colorectal cancer liver metastases, which is unresectable, intolerant to surgical resection, or refused surgical resection; 3. Intrahepatic lesions with a diameter of ≤4cm, and the number of lesions ≤3.; 4. At least 3 months since the last systemic treatment and at least 1 month since the last local treatment; 5. Child-Pugh class A or B; 6. ECOG PS ≤ 2. Exclusion Criteria: 1. Liver function Child-Pugh class C , severe jaundice, especially obstructive jaundice; 2. Diffuse liver cancer, or with tumor thrombi in the main portal vein to secondary branches or hepatic vein; 3. Significant liver atrophy, tumor volume too large, requiring ablation range of up to one-third of the liver volume; 4. Multiple systemic metastases, expected survival \< 3 months; 5. Recent history of esophageal (gastric fundus) variceal bleeding within the past month; 6. Severe functional failure of major organs such as the liver, kidneys, heart, lungs or brain; 7. Presence of active infection; 8. Uncorrectable coagulation dysfunction and severe hematological abnormalities, with a significant bleeding tendency; 9. Refractory massive ascites, pleural effusion, or cachexia; 10. Pregnancy, disorder or inability to cooperate with treatment; 11. Any other factors deemed inappropriate for inclusion or affecting the subject's participation in the study, as determined by the investigators.