Clinical Research Directory

Inclusion Criteria: * Pregnant women over 18 years old. * Gestational age between 24 - 28 weeks. * New diagnosis of gestational diabetes mellitus using a 2-hour glucose tolerance test. * Medical therapy is indicated to control blood glucose following the failure of diet and lifestyle changes to solely achieve glycemic control (A2GDM). Exclusion Criteria: Patients with pre-gestational diabetes. * First trimester fasting blood glucose ≥105 mg/dl or HbA1c \> 6.4%. * Major fetal anomalies. * Intrauterine growth restriction (IUGR) before 24 weeks. * Abnormal renal or liver function. * Contraindications to metformin or glyburide. * Medical treatment declined by the patient. * Direct indication to commence insulin (initial fasting blood glucose \>= 7 mmol/l or 126 mg/dl or \>= 6 mmol/l or 108 mg/dl with macrosomia or polyhydramnios). * Significant medical co-morbidities requiring continuous medical treatment in pregnancy. * Non-compliance to blood glucose self-monitoring (missing 50% or more of total readings)