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An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
Sponsor: BeOne Medicines
Summary
This is an open-label, multicenter, first-in-human dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-58067 alone, in combination with BG-89894, and in combination with standard of care therapy in participants with advanced solid tumors and with methylthioadenosine phosphorylase (MTAP) deficiency.
Official title: A Phase 1a/b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of PRMT5 Inhibitor BGB-58067 Alone and in Combination With Anticancer Agents in Patients With Advanced Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
244
Start Date
2024-10-11
Completion Date
2029-01
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Interventions
BGB-58067
Planned doses administered on specified days per protocol.
BG-89894
Planned doses administered on specified days per protocol.
Standard of Care Therapy
Administered in accordance with relevant local guidelines and/or prescribing information.
Locations (62)
Usc Norris Comprehensive Cancer Center (Nccc)
Los Angeles, California, United States
Adventhealth
Celebration, Florida, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Washington University School of Medicine
St Louis, Missouri, United States
Nyu Langone Health
New York, New York, United States
Sidney Kimmel Cancer Center
Philadelphia, Pennsylvania, United States
The University of Texas Md Anderson Cancer Center
Houston, Texas, United States
Next Dallas
Irving, Texas, United States
Next Virginia
Fairfax, Virginia, United States
Blacktown Cancer and Haematology Centre
Blacktown, New South Wales, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Monash Health
Clayton, Victoria, Australia
Austin Health
Heidelberg, Victoria, Australia
Linear Clinical Research
Nedlands, Western Australia, Australia
The Second Hospital of Anhui Medical University
Hefei, Anhui, China
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
Beijing Chest Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China
Fujian Cancer Hospital
Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China
Sun Yat Sen University Cancer Center
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
Guangxi Medical University Cancer Hospital Wuxiang Branch
Nanning, Guangxi, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Henan Cancer Hospital
Zhengzhou, Henan, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Hubei Cancer Hospital
Wuhan, Hubei, China
Yichang Central Peoples Hospital
Yichang, Hubei, China
Jiangsu Province Hospital
Nanjing, Jiangsu, China
Jiangxi Cancer Hospital
Nanchang, Jiangxi, China
The First Hospital of Jilin University
Changchun, Jilin, China
The First Hospital of China Medical University
Shenyang, Liaoning, China
The Second Affiliated Hospital of Shandong First Medical University
Taian, Shandong, China
Weifang Peoples Hospital Beichen Branch
Weifang, Shandong, China
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Shanghai East Hospital Branch Hospital
Shanghai, Shanghai Municipality, China
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China
Fudan University Shanghai Cancer Centerpudong
Shanghai, Shanghai Municipality, China
Sichuan Cancer Hospitaltianfu Branch
Chengdu, Sichuan, China
West China Hospital, Sichuan University
Chengdu, Sichuan, China
Deyangs People Hospital
Deyang, Sichuan, China
Tianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, China
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Zhejiang Provincial Peoples Hospital
Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang
Taizhou, Zhejiang, China
Rigshospitalet
Copenhagen, Denmark
Centre de Lutte Contre Le Cancer Institut Bergonie
Bordeaux, France
Institut Curie Paris
Paris, France
Institut de Cancerologie de Louest
Saint-Herblain, France
Institut Gustave Roussy
Villejuif, France
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Samsung Medical Center
GangnamGu, Seoul Teugbyeolsi, South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi, South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea
Asan Medical Center
SongpaGu, Seoul Teugbyeolsi, South Korea
Hospital Universitario Vall Dhebron
Barcelona, Spain
Start Madrid Fundacion Jimenez Diaz
Madrid, Spain
Hospital Universitario Hm Madrid Sanchinarro
Madrid, Spain
Hospital Clinico San Carlos
Madrid, Spain