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A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
Sponsor: Amgen
Summary
The main objective of the study is to characterize safety and efficacy of 2 dose levels of anvumetostat by investigator, and to evaluate anvumetostat monotherapy efficacy by Blinded Independent Central Review (BICR).
Official title: A Phase 2 Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacokinetics of Anvumetostat in Subjects With Methylthioadenosine Phosphorylase (MTAP)-Deleted Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC)
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-12-26
Completion Date
2030-11-29
Last Updated
2026-04-07
Healthy Volunteers
No
Conditions
Interventions
anvumetostat
Film-coated tablet
Locations (91)
City of Hope National Medical Center
Duarte, California, United States
City of Hope Orange County Lennar Foundation Cancer Center
Duarte, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
University of California Los Angeles
Los Angeles, California, United States
Rocky Mountain Cancer Centers
Denver, Colorado, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, United States
Hartford HealthCare Cancer Institute - Manchester
Plainville, Connecticut, United States
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States
Our Lady of the Lake Cancer Institute
Baton Rouge, Louisiana, United States
Trinity Health Saint Joseph Mercy Ann Arbor
Ann Arbor, Michigan, United States
Cancer and Hematology Centers of Western Michigan
Grand Rapids, Michigan, United States
Sarah Cannon Research Institute Oncology Partners
Nashville, Tennessee, United States
United States Oncology Regulatory Affairs Corporate Office
Nashville, Tennessee, United States
Texas Oncology Central/South Texas
Austin, Texas, United States
Sarah Cannon Research Institute
Dallas, Texas, United States
Texas Oncology - Dallas Fort Worth
Dallas, Texas, United States
US Oncology Research Investigational Products Center
Irving, Texas, United States
Texas Oncology Northeast Texas
Tyler, Texas, United States
Virginia Cancer Specialists PC
Fairfax, Virginia, United States
GenesisCare -North Shore Oncology
St Leonards, New South Wales, Australia
Calvary Mater Newcastle Hospital
Waratah, New South Wales, Australia
Mater Hospital Brisbane
South Brisbane, Queensland, Australia
Cancer Research South Australia
Adelaide, South Australia, Australia
Núcleo de Oncologia da Bahia
Salvador, Estado de Bahia, Brazil
Liga Norte-Riograndense Contra O Cancer
Natal, Rio Grande do Norte, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, Brazil
Hospital Nossa Senhora da Conceicao
Porto Alegre, Rio Grande do Sul, Brazil
Fundacao pio xII Barretos
Barretos, São Paulo, Brazil
Fund Faculdade Regional Med Sao Jose Rio Preto
São José do Rio Preto, São Paulo, Brazil
Instituto do Cancer Estado SP Icesp
São Paulo, São Paulo, Brazil
Fundacao Antonio Prudente - Hosp AC Camargo
São Paulo, São Paulo, Brazil
Instituto de Educacao Pesquisa e Gestao em Saude
Rio de Janeiro, Brazil
Centro Paulista de Oncologia
São Paulo, Brazil
Cross Cancer Institute
Edmonton, Alberta, Canada
William Osler Health System - Brampton Civic Hospital
Brampton, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
McGill University Health Centre Glen Site
Montreal, Quebec, Canada
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
Mengchao Hepatobiliary Hospital of Fujian Medical University
Fuzhou, Fujian, China
Henan Cancer Hospital
Zhengzhou, Henan, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China
Jilin Cancer Hospital
Changchun, Jilin, China
Jinan Central Hospital
Jinan, Shandong, China
Shanghai East Hospital
Shanghai, Shanghai Municipality, China
West China Hospital Sichuan University
Chengdu, Sichuan, China
The First Affiliated Hospital Zhejiang University School Of Medicine
Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Beijing Cancer Hospital
Beijing, China
Beijing Chest Hospital, Capital Medical University
Beijing, China
Masarykuv onkologicky ustav
Brno, Czechia
Fakultni nemocnice Olomouc
Olomouc, Czechia
Vseobecna fakultni nemocnice v Praze
Prague, Czechia
Fakultni Thomayerova nemocnice
Prague, Czechia
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Prince of Wales Hospital, Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Aichi Cancer Center
Nagoya, Aichi-ken, Japan
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan
Shizuoka Cancer Center
Sunto-gun, Shizuoka, Japan
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Koto-ku, Tokyo, Japan
Wakayama Medical University Hospital
Wakayama, Wakayama, Japan
Pauls Stradins Clinical University Hospital
Riga, Latvia
Riga East Clinical University Hospital
Riga, Latvia
Nederlands Kanker Instituut Antoni van Leeuwenhoekziekenhuis
Amsterdam, Netherlands
Sint Jansdal Ziekenhuis
Harderwijk, Netherlands
Erasmus Medisch Centrum
Rotterdam, Netherlands
Unidade Local de Saude de Braga, EPE
Braga, Portugal
Fundacao Champalimaud
Lisbon, Portugal
Hospital Cuf porto
Porto, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
Porto, Portugal
National University Hospital
Singapore, Singapore
National Cancer Centre Singapore
Singapore, Singapore
Cha Bundang Medical Center, Cha University
Seongnam-si, Gyeonggi-do, South Korea
Severance Hospital Yonsei University Health System
Seoul, South Korea
Ajou University Hospital
Suwon-si Gyeonggi-do, South Korea
The Catholic University of Korea St Vincents Hospital
Suwon-si, Gyeonggi-do, South Korea
Universitaetsspital Basel
Basel, Switzerland
Hopitaux Universitaires de Geneve
Geneva, Switzerland
Kantonsspital Sankt Gallen
Sankt Gallen, Switzerland
Taichung Veterans General Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Adana Sehir Egitim ve Arastirma Hastanesi
Adana, Turkey (Türkiye)
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
Ankara, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi
Ankara, Turkey (Türkiye)
Memorial Bahcelievler Hastanesi
Istanbul, Turkey (Türkiye)
Bagcilar Medipol Mega Universite Hastanesi
Istanbul, Turkey (Türkiye)