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LA Function and Dimensions As Predictors of Disease Activity in RA
Sponsor: Assiut University
Summary
the aim of this study is to * describe subclinical echocardiographic changes of the LA (dimensions and function) in patients with rheumatoid arthritis. * evaluate the correlation between Rheumatoid arthritis activity and subclinical structural changes of LA. * determine the association of LA volume index and atrial fibrillation or HFpf in RA patients. * apply Musculoskeletal Ultrasound detected synovitis to be correlated with cardiac function.
Official title: Left Atrial Function and Dimensions As Predictors of Disease Activity in Rheumatoid Arthritis Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
108
Start Date
2024-12-01
Completion Date
2026-01-01
Last Updated
2024-09-19
Healthy Volunteers
No
Conditions
Interventions
echocardography
Patients will be subjected to transthoracic echocardiography including, the following parameters will be measured: * Left ventricular (LV) dimensions: end diastolic and systolic dimensions and LV ejection fraction (EF). * Trans- mitral Doppler flow velocities including early (E) and late(A) diastolic velocities, E/A ratio. * LA anteroposterior diameter measure from 2D parasternal long axis view targeted M-mode. * LA superior-inferior and medio-lateral diameters measure from the apical 4 chamber view. * LA volume included: * Maximal LA volume measure at the end of systole * Minimal LA volume will be measured at end diastole just at the closure of the mitral valve. * Pre contractile LA volume ( LAV pre-A\] measured at P-wave onset on ECG just before atrial contraction.
musculoskeletal ultrasonography
Ultrasound detected synovitis t
lipid profile test
The lipid profile typically includes measurement of total cholesterol, HDL-cholesterol (often called good cholesterol), LDL-cholesterol (often called bad cholesterol), and triglycerides.
C reactive protein
A c-reactive protein test measures the level of c-reactive protein (CRP) in a sample of your blood. CRP is a protein that your liver makes. Normally, you have low levels of c-reactive protein in your blood. Your liver releases more CRP into your bloodstream if you have inflammation in your body. High levels of CRP may mean you have a serious health condition that causes inflammation.
Complete blood count CBC
A complete blood count, or CBC, is a blood test that measures many different parts and features of your blood, including: Red blood cells, which carry oxygen from your lungs to the rest of your body. White blood cells, which fight infections and other diseases. There are five major types of white blood cells. A CBC test measures the total number of white cells in your blood. A different test called a CBC with differential measures the number of each type of these white blood cells. Platelets, which stop bleeding by helping your blood to clot. Hemoglobin, a protein in red blood cells that carries oxygen from your lungs to the rest of your body. Hematocrit, a measurement of how much of your blood is made up of red blood cells. Mean corpuscular volume (MCV), a measure of the average size of your red blood cells.
Erythrocyte sedimentation rate (ESR).
An erythrocyte sedimentation rate (ESR) is a blood test that that can show if you have inflammation in your body. Inflammation is your immune system\'s response to injury, infection, and many types of conditions, including immune system disorders, certain cancers, and blood disorders.
x ray of the hand
The X-ray may show a hand with advanced rheumatoid arthritis. \"Bone erosion\" means cartilage and bone are worn away. \"Bone displacement\" means that a bone has moved out of its normal position. This X-ray shows how bone erosion and bone displacement can change the shape of the hand.