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Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Summary
Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-associated infections. Being a carrier of S. aureus is a known risk factor for S. aureus bacteremia. Although several mucosal sites of carriage have been described, screening for carriage is most often carried out at the nasal level, both for reasons of simplicity and because it is the predominant site of carriage of this bacterium. However, S. aureus carriage is a frequent occurrence, affecting around 1/3 of the general population.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
405
Start Date
2024-09-02
Completion Date
2025-11
Last Updated
2024-09-19
Healthy Volunteers
No
Conditions
Interventions
Nasal swab
Nasal swab to detect nasal carriage of S. aureus
Venous sampling
Peripheral venous sampling to collect peripheral blood mononuclear cells.
Antibiotic treatment
Antibiotic treatment for bacteremia (+/- 1 month), in all patients with S. aureus
Nasal swab
A new nasal swab will be taken using the same technique, to see whether or not the carriage persists
Intracellular reservoir test
In the event of positive carriage, a new intracellular reservoir test will be performed. A search for relapse (new S. aureus infection) or recurrence (S. aureus bacteremia if the 1st bacteremia was due to another pathogen) will be carried out.
Locations (1)
Centre Hospitalier Universitaire de St Etienne
Saint-Etienne, France