Clinical Research Directory

Inclusion Criteria: 1. Aged 18-45 years (including 18 and 45), no gender restriction; 2. Meets the diagnostic criteria for depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V); 3. Outpatients or inpatients; Hamilton Depression Rating Scale 17-item (HAMD-17) score ≥ 14; Mood Disorder Questionnaire (MDQ) screening negative to exclude bipolar disorder patients; and Clinical Global Impressions-Severity (CGI-S) score ≥ 4; 4. Maintained on antidepressant treatment for at least 4 weeks or not using antidepressant treatment; 5. Written informed consent obtained from the patient. Exclusion Criteria: 1. Diagnosed with other mental disorders, including schizophrenia, bipolar disorder, alcohol or substance abuse/dependence, eating disorders, etc.; 2. Individuals with intellectual disabilities or who are unable to cooperate for other reasons, or those lacking or having incomplete civil capacity during the onset of illness; 3. Suffering from neurological or organic brain diseases (such as stroke, cerebral hemorrhage, brain tumors, Parkinson's disease, epilepsy, etc.) and a history of severe traumatic brain injury; 4. Suffering from conditions with high exercise risk, such as hypertension or heart disease; 5. Currently undergoing systematic psychological therapy; 6. In the 3-minute step test, males with a recovery heart rate more than131 and females with a recovery heart rate more than 140; 7. Physically restricted individuals unable to participate in physical exercise; 8. Physical Activity Readiness Questionnaire (PAR-Q) score ≥ 2; 9. Pregnant women or individuals with contraindications to MRI examinations; 10. Individuals with severe suicidal tendencies or at risk of harming others.