Clinical Research Directory

Inclusion Criteria: * Age greater than or equal to 45 years at the time of signing informed consent * BMI greater than or equal to 30 kg/m2 * Patients with suspected CVD (\>15% pretest probability \[ESC guidelines\]), referred for cardiac CT examinations (consisting of coronary calcium scoring and coronary CT angiography) * Informed consent of the patient Exclusion Criteria: * Any of the following CV conditions within 2 months prior to study inclusion: myocardial infarction, stroke, * Hospitalization for unstable angina pectoris or transient ischemic attack or due to congestive heart failure. * Planned coronary, carotid, or peripheral artery revascularisation known on the day of inclusion * Presently classified NYHA IV heart failure * Having uncontrolled diabetes mellitus (HbA1c ≥ 11%) at day of inclusion * Having uncontrolled hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 100 mmHg) as measured at inclusion * Having severe renal impairment measured as an eGFR \< 30 mL/min/1.73 m2 at inclusion * Alanine aminotransferase (ALT) or alkaline phosphatase (APT) level \< 3.0 x the upper limit of normal (ULN)for the reference range * Total bilirubin level \>1.5 x the ULN for the reference range * History of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years * Previous organ transplantation or awaiting an organ transplant * Pregnancy or breastfeeding