Clinical Research Directory

Inclusion Criteria: * At least 18 years old * Be willing and able to provide informed consent to participate in the study * Patient has moderate aortic valve diseases with echocardiographically derived criteria Exclusion Criteria: * Severe aortic valve diseases with echocardiographically derived criteria or planned cardiac surgery or likely need for surgery within 6 months * Patients who have undergone elective transfemoral transcatheter aortic valve replacement * Life expectancy is less than 12 months due to non-heart disease (such as cancer, chronic liver disease, chronic kidney disease, or chronic end-stage lung disease, etc.) * Severe dementia (cannot sign research informed consent, cannot take care of themselves or complete the study visit) * Acute pulmonary oedema or cardiogenic shock * The investigator believes that the patient is not suitable to participate in the study or complete the follow-up prescribed by the protocol from other medical, social and psychological aspects * The patient is currently participating in another randomized study