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Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism
Sponsor: Qifu Li
Summary
1. Aim to investigate the pathological feature of UPA in Asians 2. To clarify the relationship between pathology, clinical phenotype, genetic mutation and surgical outcome of UPA in Asians. 3. To explore a new pathological type of unilateral primary aldosterone
Official title: Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism，A Prospective Study
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2023-12-01
Completion Date
2024-12-31
Last Updated
2024-09-19
Healthy Volunteers
No
Conditions
Interventions
Tissue specimens were stained by histopathology of hematoxylin-eosin
Whole slide images were created by scanning the complete histologic slide to produce high-resolution digital files of the histopathology of hematoxylin-eosin and CYP11B2 immunostained sections.Tissue sections of all blocks from each resected adrenal were evaluated by hematoxylin and eosin and CYP11B2 immunostaining and adrenal specimens were categorized as classical or nonclassical histopathologic findings of unilateral PA according to the HISTALDO consensus; Genotyping was performed using CYP11B2 (aldosterone synthase)-guided sequencing
Locations (1)
Qifu Li, PhD
Chongqing, Chongqing Municipality, China