Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis
Sponsor: Cairo University
Summary
The goal of this clinical trial is to know if rituximab can improve cognitive and hand functions in secondary progressive multiple sclerosis (SPMS) patients with high disability (EDSS 6.5 or more). The main questions it aims to answer are: Can rituximab improve cognitive and hand functions in SPMS patients? Can rituximab improve the quality of life and the Expanded Disability Status Scale (EDSS) in SPMS patients? Researchers will compare patients who receive rituximab to patient who receive placebo to see the effects of rituximab on cognition, hand functions, quality of life and EDSS. Demographic and clinical data as age, gender, disease duration and EDSS will be obtained from each participant. Participants will perform The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS), The Nine-Hole Peg Test (9-HPT) and The MS-QLQ27 questionnaire at baseline and after one year of receiving either rituximab or placebo.
Official title: The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis: a Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
46
Start Date
2024-08-01
Completion Date
2026-09
Last Updated
2026-03-18
Healthy Volunteers
No
Interventions
Rituximab
Rituximab 1gm vial diluted on 500 ml normal saline 0.9%
Saline (NaCl 0,9 %) (placebo)
500 ml of normal saline 0.9%
Locations (1)
Kasr Alainy Multiple Sclerosis Unit (KAMSU), Cairo University hospitals.
Giza, Giza Governorate, Egypt