Inclusion Criteria:
1. Males and females from 18 to 65 years of age
2. Caucasian
3. Diagnosis of non-metastatic colorectal cancer (stages I-III) (documented)
4. Diagnosis of persistent cancer-related fatigue with moderate or severe symptoms of cancer-related fatigue (≥ 4 on 0-10 Numerical Rating Scale (NRS) and a Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) Fatigue subscale (FACIT-F FS) score of ≤ 34 for assessment of average fatigue in the week before visit 1, both assessed at visit 1)
5. Cancer-related fatigue present since at least 4 weeks before visit one at a stable level (self-reported)
6. Cancer treatment completed (as reported by the attending physician before the study) considering the following conditions:
* a minimum of 4 weeks after the end of the last cancer-related therapy (e.g. chemotherapy, radiotherapy)
* a minimum of 6 weeks after any cancer-related surgery (if any)
7. Serum C-reactive protein (CRP) levels greater than 3 mg/l at visit1/ Screening
8. Stable medication for comorbidities (if any)
9. Established cancer-related fatigue management regime in line with current guidelines, if any, since at least 4 weeks (e.g., physical exercise counseling, medication/supplementation, nutritional counseling, psychosocial counseling)
10. Expectedly to keep level of activity (including e.g. work/educational activities, physical activity) and dietary habits during the study, including caffeine consumption and liquid intake
11. Negative pregnancy test at V1 and willingness to use a reliable method of contraception during the study in women of childbearing potential
12. Readiness and ability to understand and comply with study requirements as judged by the investigator (to take the IP as recommended)
Exclusion Criteria
1. Rapidly progressing cancer without reasonable treatment options and/or serious worsening of cancer disease during the study, as well as the need for any cancer treatment that expectedly may need to start and/or cancer-related fatigue management that expectedly may need to start/get modified during the study
2. Severe anemia (hemoglobin (Hb) ≤ 8 g/dl within last 2 weeks before or at visit 1
3. Acute illness or uncontrolled chronic metabolic illness (including diabetes mellitus, hyperthyroidism, hypothyroidism, and excluding adequately medicated hypothyroidism), uncontrolled pain, and other disorders known to cause fatigue complaints (such as heart failure, chronic obstructive pulmonary disease (COPD), severe deconditioning and/or sarcopenia, severe and unresponsive inflammation, severe damage of gastrointestinal organs impairing oral food intake and digestion, parenteral nutrition, decreased calorie intake due to substantial appetite loss), all as per investigator's judgment
4. Psychiatric disorders, including recently occurred (within the last 12 weeks before visit 1) or severe depression as judged by the investigator (stable treatment with low-dose selective serotonin reuptake inhibitors (SSRIs) is permitted)
5. Known HIV infection, hepatitis B or C, or active tuberculosis (self-reported)
6. Major surgery within 4 weeks before study or planned surgery during the treatment period
7. Consuming any other food supplements / FSMPs during the study, e.g. ginseng, guarana, mistletoe
8. History of or current abuse of medication, e.g. opioids, drugs, or alcohol
9. Participation in another study during the last 30 days before and during the study
10. Breastfeeding
11. Any other reason for exclusion as per the investigator's judgment, e.g. hypersensitivity or allergy to the IP, (expected) insufficient compliance with study procedures (due to substantial cognitive complaints related to cancer-related fatigue or other cause)
