Clinical Research Directory

Inclusion Criteria: 1. Patient who has received localised brain irradiation or craniospinal irradiation for a brain tumour whose treatment includes first-line radiotherapy. 2. Patient with one of the following tumour types: ependymomas, medulloblastomas, malignant germ cell tumours, craniopharyngioma, pinealoblastoma. 3. Patient aged between 4 and 12 years at the time of radiotherapy treatment. 4. End of irradiation within 2 years (+/-3 months) prior to inclusion. 5. Patient having been treated by photontherapy or proton therapy. 6. Sufficient visual, auditory (with authorised hearing aid) and oral or written expression capacity to carry out the neuropsychological tests properly. 7. Proficiency in the French language by the patient and parent(s). 8. Patient affiliated to a Social Security scheme in France. 9. Informed consent signed by the patient/legal parent(s)/guardian(s) in accordance with French law and Good Clinical Practice. Exclusion Criteria: 1. Patient presenting with severe ataxia. 2. Patient with a recurrence of the disease. 3. Not applicable since protocol version 2. Metastatic patient. 4. Any contraindication to MRI for patients included in Toulouse (i.e. in particular patients with a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, patients with haemostatic clips on intracerebral aneurysms, patients with orthopaedic implants, claustrophobic patients). 5. Patients undergoing psychostimulant or psychotropic treatment (in particular methylphenidate, antidepressants). 6. Any psychological, family, geographical or sociological condition that prevents compliance with medical monitoring and/or the procedures set out in the study protocol. 7. Patients deprived of their liberty or under legal protection. 8. Severe posterior fossa syndrome with akinetic mutism.