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Nitazoxanide for Treatment of Cryptosporidium in Children
Sponsor: Johns Hopkins Bloomberg School of Public Health
Summary
The goal of this clinical trial is to learn if nitazoxanide (NTZ) can treat Cryptosporidium infection in children age 6-12 months. The main questions it aims to answer are: * Does NTZ treatment of diarrheal Cryptosporidium infection lower the number of days of diarrhea? * Does NTZ treatment of diarrheal and non-diarrheal Cryptosporidium infection lower the number of days that parasites can be found in the stool? Researchers will compare NTZ to a placebo (a look-alike substance that contains no drug) to see if NTZ works to treat Cryptosporidium. Participants will: * Take NTZ or placebo for 3 days * Receive regular visits from field research assistants * Provide blood and urine samples
Official title: Randomized Control Trial of Nitazoxanide for the Treatment of Cryptosporidium Infection in Malnourished Children in Bangladesh
Key Details
Gender
All
Age Range
6 Months - 12 Months
Study Type
INTERVENTIONAL
Enrollment
480
Start Date
2026-04-01
Completion Date
2030-05
Last Updated
2026-02-12
Healthy Volunteers
No
Conditions
Interventions
Nitazoxanide
5 mL suspension (100 mg), 2x/day for 3 days
Placebo
identical in consistency, appearance, and taste to nitazoxanide suspension. 5 mL suspension given 2x/day for 3 days