Clinical Research Directory

Inclusion Criteria: 1\. Due for 2nd or 3rd colonoscopy with prior diagnosis of tubular, villous, or serrated polyps but no current diagnosis of CRC. Exclusion Criteria: 1. Inability to provide informed consent and engage in informed consent procedures. 2. Participants who suffer from allergic reactions to, or are unwilling to consume, any components of the dietary intervention. 3. Pregnant 4. Serious illness and in hospice or palliative care for terminal disease 5. Swallowing issues, including self-reported difficulty tolerating solids or liquids. 6. Active antibiotics use for an ongoing acute infection. 7. Any disorder, unwillingness, or inability not covered by any other exclusion criteria which, in the investigator's and/or team's opinion jeopardizes the safety of the participant or others or would interfere with adherence to the protocol. 8. Participants who plan to relocate to an area not served by UCSD or travel plans that do not permit completion of the study. 9. Possible ethanol (alcohol) use disorder defined by Alcohol Use Disorders Identification Test (AUDIT) score of \>15 Uncontrolled disease states: 10. Hyper-tension \>160/100mmHg 11. Exacerbation of underlying gastrointestinal disease, including chronic inflammatory bowel disease or other malabsorptive disorders 12. Decompensated cirrhosis 13. Previously diagnosed Diabetes Mellitus with HbA1c \>9% at screening 14. Newly diagnosed diabetes within the past three months, or HbA1c \>6.5% at screening in a person not previously diagnosed with diabetes. 15. Participants with a history of end-stage renal disease (ESRD) on hemodialysis 16. Active infectious diseases (e.g., active tuberculosis \< 3 months from symptom onset or positive test, COVID \< 1 month from symptom onset or positive test) 17. Participants who require dietary restrictions due to a medical condition or are on a prescribed diet for underlying chronic diseases. 18. Participants with Type 1 or Type 2 diabetes on insulin 19. Participants aged 2: 75 years with Type 2 diabetes taking prescribed medications that can cause hypoglycemia (e.g., sulfonylureas, glinides), or on a prescribed diet 20. Hospitalization for a chronic disease (e.g., congestive heart failure, stroke) within the past three months 21. Requiring transfusions/apheresis during study period 22. Participants with a current diagnosis of, or who have received treatment for, bulimia or anorexia nervosa within the past 3 years 23. Participants with major psychiatric disorders, including major depression, schizophrenia, or psychosis, who have been hospitalized in the past six (6) months or are currently enrolled in treatment programs. 24. Hemoglobin \<9.5 g/dL at screening 25. Myocardial infarction, invasive cardiac procedure, participation in a cardiac or acute rehabilitation programs, transient ischemic attacks, or unstable arrhythmias within the past 3 months.