Clinical Research Directory
Browse clinical research sites, groups, and studies.
Innovate, Involve, Inspire
Sponsor: Frontline AIDS
Summary
The study will test a Community-based Simplified HCV Testing and Treatment Algorithm (CBSA), implemented at community harm reduction fixed or mobile sites. All potential participants with positive anti-HCV test will undergo diagnostic procedures including HCV-RNA testing. Those eligible for CBSA will be prescribed a fixed dose combination tablet: sofosbuvir/daclatasvir. Sustained virologic response (SVR) will be assessed 12 weeks after treatment completion. All those who achieve SVR will be tested for HCV\_RNA at six and 12 months after SVR12.
Official title: Community-based HCV Testing and Treatment of People Who Inject Drugs: Innovate, Involve, Inspire
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
1454
Start Date
2025-01
Completion Date
2026-07
Last Updated
2024-09-19
Healthy Volunteers
Yes
Conditions
Interventions
Community-based Simplified HCV Testing and Treatment Algorithm
The distinctive features of CBSA are: (i) community-based service provision, substantially lowering the threshold for HCV services and eliminating the need to visit health care facilities for the majority of patients; (ii) the use of simple, once-daily, pan-genotypic HCV treatment regimens; (iii) a minimum of required laboratory tests and assessments; (iv) task sharing of essential functions from physicians to the case-managers; (v) integration of HCV testing and treatment with existing harm reduction services, addressing multiple health needs and facilitating patient-centered care.