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Understanding the Transition from Normal Melanocytes to Nevus to Melanoma
Sponsor: Fundacion Clinic per a la Recerca Biomédica
Summary
The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.
Official title: Understanding the Transition from Normal Melanocytes to Nevus to Melanoma (NevustoMel)
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2024-01-01
Completion Date
2026-11-30
Last Updated
2025-02-27
Healthy Volunteers
No
Interventions
Methylomics
Methylomics analysis of FFPE blocks and frozen tissues
RNA sequencing
RNA sequencing of FFPE blocks and frozen tissues
Spatial transcriptomics
Spatial transcriptomics of FFPE blocks and frozen tissues
Liquid biopsy
cfDNA characterization extracted from blood/saliva
Locations (2)
French National Institute of Health and Medical Research
Marseille, France
Hospital Clínic de Barcelona (Dermatology service)
Barcelona, Spain