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Precision Medicine for L/GCMN and Melanoma 2
Sponsor: Fundacion Clinic per a la Recerca Biomédica
Summary
The primary objective is to evaluate the possibility of using minimally and non-invasive technologies (skin patch and breath analyzer) based on the detection of volatile organic compounds (VOCs) for the early identification of metastases. The secondary objective is to evaluate the usability of these technologies in the follow up of high-risk melanoma patients.
Official title: Precision Medicine for L/GCMN and Melanoma 1 (Precis-mel 2)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-01-01
Completion Date
2026-12-01
Last Updated
2025-02-27
Healthy Volunteers
No
Interventions
Breath analyzer
The study subject will be advised to sit quietly for minimum 10 minutes prior the sampling to avoid temporal changes in levels of volatile organic compunds (VOCs) related to body movement or try to avoid abrupt changes in body posture. Then, he/she will be asked to blow in the breath analyzer in order to obtain the exhaled VOCs profile.
Skin patch
A skin patch will be placed in the anterior part of the patient's arm for the obtention of the skin VOCs profile (estimated sampling time of around 1 h). These profiles will be recorded with a dedicated software and analyzed using standard statistical methods.
Liquid biopsy
Circulating free tumor DNA (cfDNA) will be extracted from patient's blood and analyzed to detect mutations in BRAF and other prognostic genes.
Locations (3)
Hospital Clínic de Barcelona (Dermatology service)
Barcelona, Spain
Hospital Clínic Barcelona
Barcelona, Spain
Hospital Clínic Barcelona
Barcelona, Spain