Clinical Research Directory

Inclusion Criteria: * Men resident in Spain who are scheduled for open inguinal hernia repair (inpatient or outpatient procedures). * Risk of post-surgical pain chronification \> 27% using the GENDOLCAT risk scale. Exclusion Criteria: * Age under 18 years * Patients who in the recruiter's opinion have insufficient knowledge of Spanish to understand the trial * Patients who are currently being treated with duloxetine * Patents with known allergy to duloxetine * Serious renal failure (creatinine clearance \>30 ml/min) * Patients requiring reoperation because of surgical complications * Transplanted patients * History of coronary artery disease, including previous myocardial infarction, angina, percutaneous transluminal coronary angioplasty * History of congestive heart failure * Currently taking a monoamine oxidase inhibitor or other medication with substantial interaction with duloxetine * Antidepressant use within 4 weeks of study start * Treatment with inhibitors of cytochrome P450 mixed-function oxidase system (CYP1A2): fluvoxamine, ciprofloxacin or enoxacin * Uncontrolled hypertension * Bipolar disorder * History of seizures * Elevated intraocular pressure or risk of acute glaucoma * Treatment with selective serotonin reuptake inhibitors (SSRIs) * Treatment with serotonin and noradrenaline reuptake inhibitors (SNRIs) * Treatment with tricyclic antidepressants * Treatment with triptans * Treatment with antipsychotic drugs * Treatment with dopamine antagonists * Treatment with oral anticoagulant agents * Treatment with Hypericum perforatum * Major depression disorder