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Opioid-free Anesthesia Protocol for Neurosurgical Supratentorial Tumor Resection
Sponsor: Beijing Tiantan Hospital
Summary
Opioids have many side effects, such as constipation, urinary retention, itchy skin, respiratory depression, and postoperative nausea and vomiting. These side effects can lead to delayed recovery, longer hospital stays, and increased health care costs. Opioid-free anesthesia is the combination of anti-nociceptive drugs to block the different pathways involved in the transmission of nociceptive information, control pain, avoid opioid-related adverse reactions, and promote patient recovery. At present, opioid-free anesthesia is not widely used in craniocerebral surgery in neurosurgery, and the relevant clinical data are extensive. Therefore, the investigators urgently need to conduct a randomized controlled study to provide clinical evidence for the efficacy and safety of opioid-free anesthesia in neurosurgical patients.
Official title: Opioid-free Anesthesia Protocol on the Quality of Recovery After Neurosurgical Supratentorial Tumor Resection: A Randomized, Controlled, Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
170
Start Date
2024-10-21
Completion Date
2026-03-31
Last Updated
2025-03-11
Healthy Volunteers
No
Conditions
Interventions
the opioid-based control group
Intraoperative analgesia will be administered with conventional opioid drugs such as sufentanil and remifentanil.
the opioid-free anesthesia group
The patients will be administered with an opioid-free strategy during surgery. The investigator will use esketamine, dexmetopidine, and local anesthesia to control perioperative pain.
Locations (1)
Beijing Tiantan Hospital
Beijing, China