Clinical Research Directory

Inclusion Criteria: * 1.Age ≥75 years old; * 2.Have degenerative spinal diseases, including cervical, thoracic and lumbar spine diseases; * 3.With severe neurological symptoms fail to conservative treatment and have to undergo the spinal fusion surgery; * 4.No serious cognitive impairment (MoCA score ≥8); * 5.No surgical contraindications; * 6.Anesthesia assessment patients can safely undergo surgery; * 7.Patients who voluntarily participate in and sign informed consent, can independently complete effective questionnaires, and are willing to follow up according to clinical requirements. Exclusion Criteria: * 1.Patients who could not cooperate with doctors to complete preoperative evaluation and postoperative follow-up; * 2.Patients requiring spinal intervention due to spinal infection, fracture or metastatic disease; * 3.Patients with cerebrovascular accidents in the last 30 days; * 4.Patients with hepatic encephalopathy or acute active hepatitis; * 5.Patients with severe renal insufficiency with creatinine\>2.5mg/dL or undergoing hemodialysis; * 6.Patients with severe lung and cardiovascular diseases, coagulation disorders, and anesthesia contraindications; * 7.Patients with poorly controlled diabetes (HBAlc\>8.0%); * 8.Patients who are participating in clinical trials of other drugs or medical devices; * 9.Patients requiring emergency surgery; * 10.Patients who are considered by the investigator to be unable to participate in this clinical trial due to other circumstances.