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The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated With the Post-acute Phase of the Infection by Covid-19
Sponsor: Hellenic Institute for the Study of Sepsis
Summary
More than 660 million cases of COVID-19 have been reported worldwide, with 183 million cases in the EU alone. In several people, after recovery, the effects of the first waves of COVID-19 persisted beyond the acute phase and increased the risk of chronic multiorgan symptoms and disease. Up to 70% of people affected by COVID-19 showed reduced organ function even four months or more after COVID-19 diagnosis. Such a functional decline is associated with an increased risk of the development of non-communicable diseases (NCDs). Thus, there is an essential need for a better knowledge, tools, clinical guidelines and recommendations that it will make it possible to reduce this overrepresentation of NCDs as a consequence of the post-acute phase (PAP) of COVID-19. The overall concept underpinning "POINT" is to i) build detailed knowledge on the link between the PAP of COVID-19 caused by previous, current, and future SARS-CoV-2 variants in vaccinated and unvaccinated people, and NCDs, ii) identify robust biomarkers and build predictive tools that help early identification and management of risk of NCDs, and iii) develop guidelines and recommendations for all parts of the healthcare value chain, allowing best prevention and care acknowledging vulnerability. The investigators will focus on the NCDs affecting pulmonary, cardiovascular and renal systems.
Official title: A Non-interventional, Prospective, Cross-sectional Study of the Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated With the Post-acute Phase of the Infection by Sars-Cov-2
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
345
Start Date
2024-12-10
Completion Date
2027-11-04
Last Updated
2025-11-17
Healthy Volunteers
Yes
Interventions
Blood samples
Blood sampling for proteomics and transcriptomics, suPAR measurement \& isolation and stimulation of peripheral blood mononuclear cells, eGFR, serum creatinine, cystatin c \& urea
Six-minute walk test, Spirometry, HRCT, Heart ultrasound, Completion of questionnaires of symptoms
Spirometry for forced expiratory volume in the first, second, total lung capacity and diffusion capacity of carbon monoxide.
Locations (6)
10th Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
4th Department of Internal Medicine, ATTIKON University General Hospital
Athens, Greece
Obstructive Diseases Clinic, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
Out-patient department of Infectious Diseases, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
1st Department of Internal Medicine, Thriasio General Hospital of Elefsina
Elefsina, Greece
2nd Department of Internal Medicine, Thriasio General Hospital of Elefsina
Elefsina, Greece