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Efficacy and Safety of Weifuchun Tablet in Reversing Gastric Intestinal Metaplasia
Sponsor: Yongquan Shi
Summary
The goal of this clinical trial is to investigate the efficacy and safety of Weifuchun tablet in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. The main questions it aims to answer are: Does Weifuchun tablet promote the regression of gastric intestinal metaplasia in individuals without Helicobacter pylori infection? What medical problems do participants experience when taking Weifuchun tablet? Researchers will compare the effectiveness of Weifuchun tablet in treating gastric intestinal metaplasia with that of folic acid, as suggested by the Chinese consensus on management of gastric epithelial precancerous conditions and lesions (2020). Participants will: Take Weifuchun tablets or folic acid every day for 6 months. Visit the clinic once every 4 weeks for checkups and tests.
Official title: Efficacy and Safety of Weifuchun Tablet in Reversing Gastric Intestinal Metaplasia: A Multi-center, Open-label, Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2025-02-28
Completion Date
2027-12-31
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
Weifuchun
Subjects will be instructed to take four tablets (1400mg) of Weifuchun three times daily, and visit the hospital every 4 weeks for evaluation of the subjective symptoms and to receive a new supply of medication.
Folic Acid
Subjects will be instructed to take one tablet (5mg) of folic acid three times daily, and visit the hospital every 4 weeks for evaluation of the subjective symptoms and to receive a new supply of medication.
Locations (9)
Ankang Central Hospital
Ankang, China
Tongchuan People's Hospital
Tongchuan, China
Weinan Central Hospital
Weinan, China
The 986th Hospital of Air Force Medical University
Xi'an, China
Xijing hospital
Xi'an, China
Xi'an Central Hospital
Xi'an, China
Xi'an Honghui Hospital
Xi'an, China
Xunyang People's Hospital
Xuchang, China
Affiliated Hospital of Yan'an University
Yanan, China