Clinical Research Directory

Inclusion Criteria: * A score of 3.5 or less on the Expanded Disability Status Scale (EDSS) because individuals with an EDSS score greater than 3.5 need more assistance, being less independent (Zorina et al.,2020). * All patients are taking their conventional medical treatment of relapsing-remitting stage * Age over than 18 years * All definite multiple sclerosis patients diagnosed as MS according to revised McDonald criteria 2017 . * Both males and females will be included * All Patients will be referred from neurologist. Exclusion Criteria: Patients will be excluded if their diagnosis is not clearly established, if they suffer from an acute relapse or severe cognitive deficits, or have signs of any psychiatric disease -Brain surgery/trauma/history of brain disease (stroke), other independent neurological history * Another exclusion criterion is the history of cardiac, pulmonary, orthopedic,or other medical conditions diagnosed before participation * Rheumatic diseases and other acute or chronic inflammations * Vascular disease, spinal cord compression, vitamin B 12 deficiency * Other conditions that affect the smooth progress of the inspection: such as hearing impairment, comprehension impairment, poor compliance * Alcoholism or drug dependence (addiction) * Pregnancy