Clinical Research Directory

Inclusion Criteria: * Adult population of both sex, aged 20 or older admitted to the ICU with a diagnosis of sepsis were screened for inclusion within 48 h of presentation to the hospital. Sepsis was defined as per the Sepsis-3 definition, 6 ie, the presence of suspected or documented infection with organ dysfunction determined by an acute increase of sequential organ failure assessment (SOFA) score by 2 or more points Exclusion Criteria: * Patient refusal. * History of surgery in the last 7 days from admission. * Immunocompromised population ( post-transplantation, steroid use \> 5 mg per day, malignancy, HIV, on chemotherapy). * Population with history of thrombocytopenia ( ITP, aplastic anemia, drug induced) * History of thrombocytosis ( idiopathic thrombocytosis, post-splenectomy) * History of platelet transfusion one week before admission. * Bone marrow transplanted population . * Chronic liver and kidney disease. * Von-Willebrand disease. * Patients on antiplatelet therapy ( Aspirin, clopidogrel). * Thrombocytopenic population ( ITP, TTP,HELLP) . * Myelodysplastic or proliferative patients. * Blood dyscarsiasis * Obestetric parturients.