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Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Summary
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.
Official title: Intravenous Acetaminophen After Cardiac Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1100
Start Date
2024-07-02
Completion Date
2027-12-15
Last Updated
2024-09-25
Healthy Volunteers
No
Interventions
acetaminophen
Patient receive IV acetaminophen (and oral placebo) or placebo IV acetaminophen and oral acetaminophen. All drugs are blinded
Locations (8)
University of British Columbia
Vancouver, British Columbia, Canada
University of Manitoba
Winnipeg, Manitoba, Canada
Trillium Health Centre
Mississagua, Ontario, Canada
University of Ottawa
Ottawa, Ontario, Canada
Sunnybroook Health Centre
Toronto, Ontario, Canada
McGill Universtiy Health Centre
Montreal, Quebec, Canada
Universite Montreal
Montreal, Quebec, Canada
University of Laval
Québec, Quebec, Canada