Clinical Research Directory

Inclusion Criteria: * Male or female, aged 22 - 75 * Has been typically suffering from at least three heartburn and/or regurgitation episodes per week during the past three months. * Undergone a wireless (Bravo) pH monitoring test during the past 24 months prior to enrollment into the current study, following a 7-day (min.) off-PPI period, with AET ≥6% (as defined in section 7.2) in at least 2 monitoring days AND when averaged over all monitoring days of the test; or Undergone a catheter-based pH monitoring test during the past 24 months prior to enrollment into the current study, following a 7-day (min.) off-PPI period, with AET ≥6% (as defined in section 7.2). * Able and willing to give informed consent for participation in the study and to comply with all study requirements, including operating the smartphone application. * Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study. Exclusion Criteria: * Previously undergoing gastric or esophageal surgery * Active peptic ulcer disease * Esophageal or gastric varices or esophageal peptic stricture * Severe dysphagia * History of suspected or confirmed esophageal or gastric cancer * History of any other malignancy in the last 2 years * Pregnant women or women intending to become pregnant during the trial period * Uncontrolled diabetes mellitus, defined as HbA1c \> 7.5% * Severe cardiac conditions such as cardiac arrhythmia or ischemia or cardiac pacemaker / defibrillator * Having any implanted electrical device (e.g. sacral nerve stimulation, brain stimulator, others) * Known allergy to the device's adhesives/patches * Severe pulmonary diseases * History of significant multisystem diseases (e.g. kidney failure, liver failure) * Known autoimmune or a connective tissue disorder (e.g. scleroderma, CREST-syndrome, Sjogren's Syndrome), requiring therapy in the preceding 2 years * History of Barrett's esophagus * Para-esophageal hiatal hernia * Known history of sliding hiatal hernia ≥4 cm in the last 3 years * Known history of erosive esophagitis Grade C or D (LA classification) in the past 5 years * Obesity, defined as BMI\>32 * History of gastroparesis * History of fibromyalgia, epilepsy, endometriosis * Umbilical hernia \>3cm * Past usage experience with the study device * Those currently enrolled in any other interventional clinical study * Inability to sign the informed consent * Inability to understand and fill the reports and questionnaires included in the study * Inability to follow the study requisites * Other medical conditions/medications that would interfere with subject safety or data collection in the opinion of the PI