Clinical Research Directory

Inclusion Criteria: * Age between 50-80 years old; * A clear diagnosis of age-related cataract, having completed the first eye cataract surgery at our hospital, and planning to have the second eye cataract surgery with the same doctor; * The interval between the two surgeries is ≤30 days; * Capable of cooperating to complete iris optical coherence tomography angiography examination; * Based on our team\'s previous research, a predictive scoring formula for pain during the second eye surgery has been derived (Predicted score = 1.36 + 4.93 \* preoperative iris vessel area density - 0.24 \* surgical interval (weeks)), and the calculated predicted score is \>2. Exclusion Criteria: * History of ocular trauma, ocular surgery, uveitis, fundus disease, glaucoma, or recent history of episcleritis, keratitis, severe dry eye, and other ocular surface disease episodes; * Participation in intraocular or systemic medication clinical trials within the past 6 months; * Having an autoimmune disease or currently undergoing immunosuppressive therapy; * Having a psychiatric disorder such as anxiety or depression; * History of using glucocorticoid eye drops for treatment in the second eye within the past month; * Long-term use of drugs that can cause intraoperative floppy iris syndrome, such as alpha-blockers; * Severe complications occurred during or after the first eye surgery (e.g., posterior capsule rupture, zonular exercise, nuclear drop into the vitreous cavity, postoperative endophthalmitis, glaucoma, etc.).