Clinical Research Directory

Inclusion Criteria: * Age ≥18，both sexes; * Diagnosed with a history of glioblastoma, and the recurrent glioblastoma has confirmed by histological/molecular pathology (including astrocytoma World Health Organization (WHO) Grade 4); * Karnofsky (KPS) ≥50; * The estimated survival time is ≥12 weeks; * Blood pregnancy tests for women of childbearing age are negative; * The patient himself/herself, and/or his/her legal guardian, agree to participate in the trial and sign the informed consent form. Exclusion Criteria: * Known allergies to study drugs or drugs that may be used in the study; * Severe concurrent diseases in the heart, lungs, liver, or other vital organs; * Hypertension is poorly controlled or accompanied by hypertensive crisis or hypertensive encephalopathy; * In addition to the glioblastoma, with other severe central nervous system diseases or complications or aggressive malignancies; * Long-term use of immunosuppressant drugs, or large doses of steroids; * Received live or attenuated vaccine or other surgery had no related to GBM within 4 weeks prior to Lymphocytes apheresis; * Lymphocytes apheresis or cell infusion combined with infection or unexplained fever.