Clinical Research Directory

Inclusion Criteria: * 18-80 years old with an ischemic or hemorrhagic stroke that occurred ≥6 months prior; * Ability to give consent; * Unilateral limb (left or right) weakness with Fugl Meyer-Upper Extremity Scale score of 19-53/60 points which indicates adequate arm/hand use for rehabilitation tasks; * active wrist flexion/extension ≥10° with active abduction/extension of thumb and at least 1 digit ≥10° to further assure ability to participate in rehabilitation tasks; * Passive range of motion in affected shoulder, elbow and wrist within 20 degrees of normal values. Exclusion Criteria: * Other concomitant neurological disorders affecting upper extremity motor function; * Presence of Dysphagia or aspiration difficulties; * Prior injury to vagus nerve; * Pregnancy; * Documented history of dementia before or after stroke; * Documented history of uncontrolled depression or psychiatric disorder either before or after stroke which could affect their ability to participate in the experiment; * Uncontrolled hypertension; * Botox injections within 4 weeks of the first day of rehabilitation therapy.