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Connectomic Guided DBS for Parkinson's Disease
Sponsor: Duke University
Summary
The objective of this research is to use advanced connectomic imaging models to identify disease-relevant axonal pathway targets for better tremor control in Parkinson's disease patients while avoiding undesirable side effects, with the goal of increasing precision and facilitating the choice of optimal DBS parameters for certain disease phenotypes. The investigators hypothesize that patient centered subthalamic nucleus deep brain stimulation of cerebellothalamic axonal pathways and pallidothalamic tract activation can provide better tremor control while avoiding worsening dyskinesias in patients with Parkinson's disease with significant tremor.
Official title: Connectomic Guided Deep Brain Stimulation (DBS) for Parkinson's Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-02-16
Completion Date
2027-01-29
Last Updated
2026-02-20
Healthy Volunteers
No
Conditions
Interventions
Cerebellothalamic optimized deep brain stimulation
A deep brain stimulation plan will be created by maximizing the cerebellothalamic pathway on the patient-specific connectomic deep brain stimulation model
Pallidothalamic optimized deep brain stimulation
A deep brain stimulation plan will be created by maximizing the Pallidothalamic pathway on the patient-specific connectomic deep brain stimulation model
No deep brain stimulation
Patients will also be tested without any deep brain stimulation
Usual care deep brain stimulation
Patient will also be tested with the deep brain stimulation clinical settings that were previously established during usual care with their neurologist
Locations (1)
Duke Health Center at Morreene Road
Durham, North Carolina, United States