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Relationship Between Biological Phenotype, Clinical Severity of Sickle Cell Disease, and Blood Coagulation
Sponsor: Hospices Civils de Lyon
Summary
Sickle cell disease is characterized by chronic hemolytic anemia and blood rheological alterations. In addition, blood coagulation abnormalities have been reported in patients with sickle cell disease and hemolysis-derived products could be involved. The investigators hypothesized that patients with sickle cell disease and severe hemolysis (Lactate Dehydrogenase level \> 484 IU/L) could have an increased risk of hypercoagulable state and subsequent thromboembolic complications.
Key Details
Gender
All
Age Range
8 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2025-02-01
Completion Date
2028-02-01
Last Updated
2025-01-15
Healthy Volunteers
No
Conditions
Interventions
blood sampling
3 additional citrate tubes (2.7mL)
Locations (2)
Insitut Hématologique et Oncologique Pédiatrique (IHOPe)
Lyon, France
Service de Médecine Interne - Hôpital Edouard Herriot
Lyon, France