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A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
Sponsor: Deciphera Pharmaceuticals, LLC
Summary
The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD. Participants will be treated with vimseltinib in 28-day treatment cycles for approximately 2 years.
Official title: A Phase 2, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, PK, and Efficacy of Vimseltinib in Adults With Active Chronic GVHD After Failure of Prior Systemic Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2024-11-21
Completion Date
2029-10
Last Updated
2025-12-15
Healthy Volunteers
No
Interventions
Vimseltinib
Administered orally
Locations (26)
City of Hope National Medical Center
Duarte, California, United States
Ronald Regan UCLA Medical Center
Los Angeles, California, United States
University of California Irvine Health
Orange, California, United States
AdventHealth Orlando
Orlando, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
Emory University Winship Cancer Institute
Atlanta, Georgia, United States
University of Illinois Medical Center - Hematology & Oncology
Chicago, Illinois, United States
University of Kansas Cancer Center-Westwood
Westwood, Kansas, United States
University of Kentucky Markey Cancer Center
Lexington, Kentucky, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Henry Ford Cancer Institute
Detroit, Michigan, United States
Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, United States
Levine Cancer Institute
Charlotte, North Carolina, United States
Duke University Hospital
Durham, North Carolina, United States
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Avera Cancer Institute
Sioux Falls, South Dakota, United States
Tristar Bone Marrow Transplant
Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
St. David's South Austin Medical Center
Austin, Texas, United States
UT Southwestern Medical Center
Dallas, Texas, United States
Intermountain Health
Salt Lake City, Utah, United States
Virginia Commonwealth University
Richmond, Virginia, United States