Clinical Research Directory

Inclusion Criteria: * American Society of Anesthesiology Physical Status Classification Grade of 1(normal, healthy patient) to Grade 3 (patient with severe disease) * Between ages 18-45 years old * Planned surgery duration between 60-240 minutes General-endotracheal-tube-anesthesia or general anesthesia with laryngeal mask airway * Subjects capable of giving informed consent or * Subjects who have an acceptable surrogate capable of giving consent on behalf of the subject * All contraception methods will be allowable for any subject in this study. Participants may opt-out of a pregnancy test if they would prefer to proceed with surgery without one. Pregnant women will not be strictly excluded from this study if they meet all other criteria. Exclusion Criteria: * American Society of Anesthesiology Physical Status Classification Grade of 4,5,6 (diseases that are life threatening or no possibility of survival) * Listed allergies to any commonly used anesthetic agents * History of seizures, as a seizure while using brain monitoring may influence the anesthesia provider in a way that is not aligned with the purpose of this study * Any patient undergoing emergency surgery, as can not be ensured that consent will be able to be properly obtained * Patient refusal to participate in study * Any patient undergoing surgery that would prevent placement of the Sedline monitor leads (for example - surgery on the patient's forehead/scalp) * Patients who receive neuraxial anesthesia or a peripheral nerve block as part of their anesthetic * Patients who are taking gender-affirming hormonal medications, as this can affect the response to anesthetics * The duration of surgery scheduled \<60 minutes