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A Study of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Sponsor: Ono Pharmaceutical Co., Ltd.
Summary
ONO-7018 is a selective inhibitor of mucosa associated lymphoid tissue protein 1 (MALT1) and is expected to exhibit antitumor activity in NHL. This study is Phase1 study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (biomarkers) and efficacy of ONO-7018 in patients with relapsed or refractory NHL.
Official title: A Phase 1, Open-label, Dose Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) in Japan
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2
Start Date
2024-11-27
Completion Date
2026-04-28
Last Updated
2026-07-29
Healthy Volunteers
No
Conditions
Interventions
ONO-7018
ONO-7018 tablet(s) are administered orally.
Locations (6)
Nagoya City University Hospital
Nagoya, Aichi-ken, Japan
National Hospital Organization Shibukawa Medical Center
Shibukawa-shi, Gunma, Japan
Hiroshima Red Cross Hospital Atomic-bomb Survivors Hospital
Hiroshima, Hiroshima, Japan
National Hospital Organization Sendai Medical Center
Sendai, Miyagi, Japan
National Hospital Organization Osaka National Hospital
Osaka, Osaka, Japan
The Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan