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A Study of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Sponsor: Ono Pharmaceutical Co. Ltd
Summary
ONO-7018 is a selective inhibitor of mucosa associated lymphoid tissue protein 1 (MALT1) and is expected to exhibit antitumor activity in NHL. This study is Phase1 study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (biomarkers) and efficacy of ONO-7018 in patients with relapsed or refractory NHL.
Official title: A Phase 1, Open-label, Dose Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) in Japan
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2024-11-27
Completion Date
2029-12-31
Last Updated
2025-02-18
Healthy Volunteers
No
Conditions
Interventions
ONO-7018
ONO-7018 tablet(s) are administered orally.
Locations (6)
Nagoya City University Hospital
Nagoya, Aichi-ken, Japan
National Hospital Organization Shibukawa Medical Center
Shibukawa-shi, Gunma, Japan
Hiroshima Red Cross Hospital Atomic-bomb Survivors Hospital
Hiroshima, Hiroshima, Japan
National Hospital Organization Sendai Medical Center
Sendai, Miyagi, Japan
The Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan
National Hospital Organization Osaka National Hospital
Osaka, Japan