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ACTIVE NOT RECRUITING
NCT06622226
PHASE1

A Study of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Sponsor: Ono Pharmaceutical Co. Ltd

View on ClinicalTrials.gov

Summary

ONO-7018 is a selective inhibitor of mucosa associated lymphoid tissue protein 1 (MALT1) and is expected to exhibit antitumor activity in NHL. This study is Phase1 study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (biomarkers) and efficacy of ONO-7018 in patients with relapsed or refractory NHL.

Official title: A Phase 1, Open-label, Dose Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) in Japan

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

24

Start Date

2024-11-27

Completion Date

2029-12-31

Last Updated

2025-02-18

Healthy Volunteers

No

Interventions

DRUG

ONO-7018

ONO-7018 tablet(s) are administered orally.

Locations (6)

Nagoya City University Hospital

Nagoya, Aichi-ken, Japan

National Hospital Organization Shibukawa Medical Center

Shibukawa-shi, Gunma, Japan

Hiroshima Red Cross Hospital Atomic-bomb Survivors Hospital

Hiroshima, Hiroshima, Japan

National Hospital Organization Sendai Medical Center

Sendai, Miyagi, Japan

The Cancer Institute Hospital of JFCR

Koto-ku, Tokyo, Japan

National Hospital Organization Osaka National Hospital

Osaka, Japan