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TERMINATED
NCT06622226
PHASE1

A Study of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Sponsor: Ono Pharmaceutical Co., Ltd.

View on ClinicalTrials.gov

Summary

ONO-7018 is a selective inhibitor of mucosa associated lymphoid tissue protein 1 (MALT1) and is expected to exhibit antitumor activity in NHL. This study is Phase1 study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (biomarkers) and efficacy of ONO-7018 in patients with relapsed or refractory NHL.

Official title: A Phase 1, Open-label, Dose Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ONO-7018 in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) in Japan

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

2

Start Date

2024-11-27

Completion Date

2026-04-28

Last Updated

2026-07-29

Healthy Volunteers

No

Interventions

DRUG

ONO-7018

ONO-7018 tablet(s) are administered orally.

Locations (6)

Nagoya City University Hospital

Nagoya, Aichi-ken, Japan

National Hospital Organization Shibukawa Medical Center

Shibukawa-shi, Gunma, Japan

Hiroshima Red Cross Hospital Atomic-bomb Survivors Hospital

Hiroshima, Hiroshima, Japan

National Hospital Organization Sendai Medical Center

Sendai, Miyagi, Japan

National Hospital Organization Osaka National Hospital

Osaka, Osaka, Japan

The Cancer Institute Hospital of JFCR

Koto-ku, Tokyo, Japan